Estrogens

What are estrogens?  

Estrogens are a group of hormones that play a crucial role in the female body. They are mainly produced in the ovaries and are important for various bodily functions, such as reproduction, bone health, cardiovascular function and regulating other important processes. 

There are three types of oestrogen that play a role in the female body: 

  • Estron (e1): After menopause, estrone is the dominant form. Although it is a less active form of oestrogen, it plays a role in hormonal balance. It is also produced in adipose tissue, which keeps it present after menopause.
  • Estradiol (e2): This is the most powerful and active estrogen. In women of childbearing age, it plays a vital role in the menstrual cycle, bone formation and brain function. During menopause, however, estradiol levels often drop sharply, leading to symptoms such as hot flushes, mood swings, sleep problems and bone loss. Estradiol is often used in hormone therapy to address this deficiency.
  • Estriol (e3): Estriol is a short-acting estrogen with a mild hormonal effect. It occurs mainly during pregnancy and is often used to treat local symptoms such as vaginal dryness. As it has fewer systemic effects, it is frequently incorporated into vaginal creams.
The functions of estrogens in a woman's body
Estrogens influence many aspects of health. They play an important role in: 

the menstrual cycle and fertility 
regulating the cycle and preparing the body for possible pregnancy; 
Bone health: 
They contribute to the development and maintenance of strong bones, thereby reducing the risk of osteoporosis. 
The cardiovascular system: 
Estrogens help to maintain healthy cholesterol levels and support the flexibility of blood vessels. 
The brain and mood: 
This hormone is involved in cognitive function and mood regulation. A deficiency can lead to mood swings or feelings of depression. 
Skin and mucous membranes: 
They ensure healthy skin and maintain the moisture content of mucous membranes, such as those in the vagina. 

Signs of declining estrogen levels
Although not all symptoms are included in the official treatment guidelines, there are now more than 50 conditions associated with decreased oestrogen levels. Women may notice changes as early as their mid-forties. 

In perimenopause
This transitional phase, which precedes the final menopause, is accompanied by estrogen level fluctuations. These changes can manifest as: 
  • Irregular menstruation 
  • Hot flashes and night sweats 
  • Mood swings and irritability 
  • Fatigue and sleeping problems 
  • Decreased libido 
In postmenopausal women
After the menopause, when the ovaries produce virtually no oestrogen, the following symptoms may occur: 
  • Accelerated bone loss, increasing the risk of osteoporosis 
  • Vaginal dryness and pain during intercourse 
  • Increased cardiovascular risk 
  • Changes in skin and hair 
  • Cognitive decline and an increased risk of dementia.
Hormone therapy with bioidentical estrogens:

Hormone replacement therapy (HRT) can help to compensate for estrogen deficiency and reduce menopausal symptoms. There are two main types:

Synthetic estrogens
These are often used in conventional HRT. Their structure differs from that of the body's own estrogens, which can affect how they act and break down. 
Bioidentical hormones:
These have the same molecular structure as natural estrogens and are generally used in lower doses. They are recognized more easily by the body, contributing to more effective and often safer treatment.

Learn more about


BHRT
Hormones & Menopause
Progesterone
Testosteron

Customised medication and dosage forms

Fagron Oldenzaal offers bespoke preparations, whereby the medication is customised. This includes estradiol in a personalised dosage.

Pentravan® administration
Pentravan®, a transdermal cream base that optimizes the absorption of estradiol through the skin, is an effective method of administration. This ensures accurate dosing, improved bioavailability and a more consistent release of the hormone, which may result in fewer side effects than oral administration.

Prescription and medical supervision are required.

Hormone therapy, including HRT with bioidentical estrogens, is always prescribed and strictly supervised by a doctor. Your doctor will work with you to determine the best treatment plan, taking into account possible risk factors and providing comprehensive information on the safe use of medication. The products will only be shipped after a thorough medication check has been carried out at the pharmacy.

Contact

If you have any questions or would like more information about treatment with estrogens and HRT, please email us at assistent@infinitypharma.com.

Estrogens 

What are estrogens?  

Estrogens are a group of hormones that play a crucial role in the female body. They are mainly produced in the ovaries and are important for various bodily functions, such as reproduction, bone health, cardiovascular function and regulating other important processes. 

There are three types of oestrogen that play a role in the female body: 

  • Estron (e1): After menopause, estrone is the dominant form. Although it is a less active form of oestrogen, it plays a role in hormonal balance. It is also produced in adipose tissue, which keeps it present after menopause.
  • Estradiol (e2): This is the most powerful and active estrogen. In women of childbearing age, it plays a vital role in the menstrual cycle, bone formation and brain function. During menopause, however, estradiol levels often drop sharply, leading to symptoms such as hot flushes, mood swings, sleep problems and bone loss. Estradiol is often used in hormone therapy to address this deficiency.
  • Estriol (e3): Estriol is a short-acting estrogen with a mild hormonal effect. It occurs mainly during pregnancy and is often used to treat local symptoms such as vaginal dryness. As it has fewer systemic effects, it is frequently incorporated into vaginal creams.

The functions of estrogens in a woman's body

Estrogens influence many aspects of health. They play an important role in: 

  • The menstrual cycle and fertility: 
    Regulating the cycle and preparing the body for possible pregnancy; 
  • Bone health: 
    They contribute to the development and maintenance of strong bones, thereby reducing the risk of osteoporosis. 
  • The cardiovascular system: 
    Estrogens help to maintain healthy cholesterol levels and support the flexibility of blood vessels. 
  • The brain and mood: 
    This hormone is involved in cognitive function and mood regulation. A deficiency can lead to mood swings or feelings of depression. 
  • Skin and mucous membranes: 
    They ensure healthy skin and maintain the moisture content of mucous membranes, such as those in the vagina. 

Signs of declining estrogen levels

Although not all symptoms are included in the official treatment guidelines, there are now more than 50 conditions associated with decreased oestrogen levels. Women may notice changes as early as their mid-forties. 

In perimenopause
This transitional phase, which precedes the final menopause, is accompanied by estrogen level fluctuations. These changes can manifest as: 
  • Irregular menstruation 
  • Hot flashes and night sweats 
  • Mood swings and irritability 
  • Fatigue and sleeping problems 
  • Decreased libido 
In postmenopausal women
After the menopause, when the ovaries produce virtually no oestrogen, the following symptoms may occur: 
  • Accelerated bone loss, increasing the risk of osteoporosis 
  • Vaginal dryness and pain during intercourse 
  • Increased cardiovascular risk 
  • Changes in skin and hair 
  • Cognitive decline and an increased risk of dementia.

Hormone therapy with bioidentical estrogens:

Hormone replacement therapy (HRT) can help to compensate for estrogen deficiency and reduce menopausal symptoms. There are two main types:

Synthetic estrogens
These are often used in conventional HRT. Their structure differs from that of the body's own estrogens, which can affect how they act and break down. 
Bioidentical hormones:
These have the same molecular structure as natural estrogens and are generally used in lower doses. They are recognized more easily by the body, contributing to more effective and often safer treatment.

Learn more about


Bio-identical Hormones
Read more
Hormones and menopause
Read more
Progesterone

Read more
Testosterone

Read more

Customised medication and dosage forms

Fagron Oldenzaal offers bespoke preparations, whereby the medication is customised. This includes estradiol in a personalised dosage.

Pentravan® administration
Pentravan®, a transdermal cream base that optimizes the absorption of estradiol through the skin, is an effective method of administration. This ensures accurate dosing, improved bioavailability and a more consistent release of the hormone, which may result in fewer side effects than oral administration.

Prescription and medical supervision are required.

Hormone therapy, including HRT with bioidentical estrogens, is always prescribed and strictly supervised by a doctor. Your doctor will work with you to determine the best treatment plan, taking into account possible risk factors and providing comprehensive information on the safe use of medication. The products will only be shipped after a thorough medication check has been carried out at the pharmacy.

Contact 





If you have any questions or would like more information about treatment with estrogens and HRT, please email us at assistent@infinitypharma.com.


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